Insights On Outsourced Drug Development
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Automating Cell Based Assays, Reducing Variability And Time To Results
5/16/2024
Cell-based assays present a unique challenge due to inherent biological variation in the starting materials. Explore the development of a cell-based potency assay implemented on an automated platform.
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Leveraging Post-Translational Modifications & Biofunctional Assays For The Characterization Of Charged Variants
5/14/2024
Discover how a CDMO with extensive experience in protein variant characterization, CQA analytics, and patient-centric product development can ensure the safety and efficacy of your biotherapeutic.
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Cytokine-Mediated Inflammation In A Relevant Preclinical Model
3/13/2024
Learn about a novel preclinical model and how it enables the study of cytokine-mediated barrier inflammation mechanisms as well as the efficacy of anti-inflammatory therapeutics.
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Expansion Of MDCK Cells On Microcarriers Via Growth In Stirred Vessels
8/31/2022
We demonstrate how microcarriers provide an ideal substrate for expansion of MDCK cells in closed stirred-vessel systems and lay the groundwork for subsequent developmental studies in larger bioreactor formats.
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Enhancing The Solubility Of High Lipophilicity Drugs Via Spray Drying
3/10/2023
A new R&D project shows the solubility and dissolution characteristics of Itraconazole can be improved by helping them maintain an amorphous state after spray drying with selected hydrophilic polymers.
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Organ-Chips: A Promising Model For Human Emulation
4/9/2024
Organ-Chips offer more accurate assessments of safety and efficacy readouts compared to other cell and animal models used by academia, government, and pharmaceutical entities to study drug toxicity.
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Increasing Bioavailability With Amorphous Solid Dosage Formulations
11/10/2023
Discover the challenges associated with pH-dependent solubility for oral tyrosine kinase inhibitor drugs and how leveraging ASD formulation can help create more effective, patient-friendly drug products.
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Development Of Chemically Defined Medium For Vero Cells
8/29/2022
Gain insight into a new developed, fully chemically defined and animal component free culture medium which supports Vero cell growth in static and in bioreactor cultures.
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Validated LC–MS/MS Method For The Determination Of Copanlisib
11/14/2022
Review study findings on a validated LC–MS/MS method for quantifying copanlisib from a mouse dried blood spot and its potential for enabling desirable sensitivity, accuracy, and precision.
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Investigating Key Mechanisms Of Parkinson’s With A Novel Model
4/9/2024
Efforts to develop a dynamic “brain-on-a-chip” model that closely resembles the human substantia nigra could be applied to study mechanisms of Parkinson’s disease.