Product/Service

High-Temperature Short Time (HTST) Systems

Source: Integrated Process Engineers & Constructors Inc. (IPEC)
The HTST systems are used to inactivate viruses in media before it is sent to fermentors. The HTST systems heat the media from ambient, 22ºC temperature to 102ºC. The systems hold the media at this temperature for a minimum of 10 seconds and then cool the media to 37ºC.

The HTST systems are used to inactivate viruses in media before it is sent to fermentors. The HTST systems heat the media from ambient, 22ºC temperature to 102ºC. The systems hold the media at this temperature for a minimum of 10 seconds and then cool the media to 37ºC.

Two HTST systems were rated for a 40 LPM flow rate and the third system was rated for a flow rate of 125 LPM. The media on all three systems was filtered through a .45 micron filter before heating. Media is transferred by over pressure on the preparation tanks to the HTST systems and then discharges to the fermentors.

The HTST systems are designed to be cleaned-in-place (CIP'd). CIP solutions at approximately 1.5 to 2 times the product rate are utilized to clean the systems. The solutions are acid and caustic based at 80ºC. Final rinses are also 80ºC.

Controls:
Three separate control panels were provided for each of the HTST systems. One panel contains motor control equipment for the HTST circulation pump. The second panel is a pneumatic control panel that contains all solenoids and air-regulating equipment for operation of system mounted pneumatic valves. The final panel is a low voltage control panel that contains I/O modules, voltage regulating equipment and terminals that interconnect to all system mounted devices.

Testing:
Prior to shipment, all systems were IQ and OQ checked to ensure satisfactory operation of all system mounted components. After this, the systems were Factory Wet Tested with customer representatives present. All systems were then completely passivated per customer approved procedures.