Accelerating mRNA-Based Therapy Development With Scalable Purification Of In Vitro Transcribed mRNA

By Kelly Flook, Brian Sim, Jim Molinari, Julia Baek, Sirat Sikka, and Alejandro Becerra

mRNA-based therapies have a wide range of potential, including synthetic mRNA tools used in the treatment of diseases such as cancer, stem cell therapies and infectious diseases. Current mRNA production methods require multiple purification steps and various chemicals, creating a bottleneck for some large-scale manufacturing. A new affinity chromatography resin has now been developed to address these challenges, particularly when manufacturing in vitro transcribed mRNA.

Learn more about the POROS Oligo (dT)25 resin's isolation and purification benefits and dynamic binding capacity. Achieve scalable mRNA purification process without the use of toxic chemicals.